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    Will new autoimmune drugs address cost concerns?


    The average monthly cost of drugs to treat inflammatory conditions was more than $3,000 in 2015, according to Express Scripts’ 2015 Drug Trend Report, released in March 2016. Additionally, per member per year spend on drugs to treat autoimmune diseases was $89.10 in 2015, making inflammatory conditions the leading specialty therapy class as well as the leading class overall in the report.

    “Spending on autoimmune drugs continues to increase and utilization is rising,” says April Kunze, PharmD, senior director, clinical formulary development and trend management strategy, Prime Therapeutics. “Autoimmune is the number one specialty drug spend category at Prime Therapeutics within our commercially insured business, comprising approximately one in 10 dollars spent on all drug expenditures through the medical and pharmacy benefits.”

    Current treatments

    According to Kunze, there are 15 autoimmune specialty drugs and more to be approved soon, making this class one of the fastest and most challenging to manage.

    Specialty drugs available to treat inflammatory conditions include tumor necrosis factor (TNF) inhibitors, injectable biologics, and oral targeted synthetic DMARDs (disease-modifying antirheumatic drugs), says Aimee Tharaldson, PharmD, senior clinical consultant in the emerging therapeutics department at Express Scripts.

    “The majority of the spend for autoimmune drugs is related to the biological products and especially the TNF inhibitors, says Kunze. “Humira and Enbrel are two of the top drugs by percent expenditure within Prime’s book of business (pharmacy benefit) and Remicade is the top drug on the medical benefit.”

    The oral DMARDs include Xeljanz (tofacitinib, Pfizer) and Otezla (apremilast, Celgene).

    Injectable biologics used to treat autoimmune conditions include Actemra (tocilizumab, Genentech), Stelara (ustekinumab, Janssen), Cosentyx (secukinumab, Novartis) and Taltz (ixekizumab, Eli Lilly and Company).

    Pipeline treatments

    Several new options are in the pipeline for autoimmune conditions. Saracta (sarilumab, Sanofi) is a subcutaneous injection being studied for the treatment of rheumatoid arthritis (RA). Similarly, sirukumab, a human interleukin monoclonal antibody that targets interleukin-6, is being studied by GlaxoSmithKline in adults with moderately to severely active RA. Baricitinib, developed by Eli Lilly, is a once-daily oral option for RA with anticipated approval in early 2017.

    There are also potential new options coming for the treatment of plaque psoriasis including Siliq (brodalumab, Valeant Pharmaceuticals), a monoclonal antibody that targets the IL-17 receptor.  Additionally, Tharaldson explains that IL-23 inhibitors are another important therapy class to watch for in the psoriasis pipeline. These drugs include Janssen’s guselkumab and AbbVie’s risankizumab.

    Next: How biosimilars will affect the autoimmune drug class



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