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    Watch list 2017: Top therapeutic areas

     

    Hepatitis C

    The therapeutic area of hepatitis C calmed down after the 2013 approval of Sovaldi (sofosbuvir) and Harvoni (ledipasvir and sofosbuvir) in 2014, but in June 2016, Epclusa (sofosbuvir 400 mg/velpatasvir 100 mg), the first single tablet regimen approved for treatment of all genotypes of the virus, was approved.

    Lyle says, however, that it should cost less than the initial prices of its predecessors, about $890 per pill versus $1,000 and $1,125 for Sovaldi and Harvoni, respectively. In addition, in January 2016, Zepatier (elbasvir and grazoprevir) to treat genotypes 1 and 4 in competition with Harvoni came on board costing $54,600 compared to Harvoni’s initial price of $94,500 for a course of treatment.

    CareMark will cover Harvoni, Sovaldi and Epclusa and has removed Viekira Pak from its formulary, while Express Scripts remains loyal to Viekira Pak.

    Orphan conditions

    Aimee Tharaldson, senior clinical consultant, emerging therapeutics for Express Scripts, says that although there has been a lot of attention paid to cancer drugs, there has been even more directed at orphan drugs. Cancer drugs (non-orphan status) account for 22% of the specialty drug pipeline, while orphan drugs account for 40%, she says. In addition, 30% of these drugs are expected to be blockbusters. Tharaldson shared this information as a keynote speaker at the Academy of Managed Care Pharmacy 2016 Nexus conference.

    Medications for some orphan diseases are moving through the pipeline, such as the first treatment for Duchenne muscular dystrophy (DMD) called Exondys 51 (eteplirsen) that received accelerated approval in September 2016, and corticosteroid deflazacort, also for DMD, awaits further study.

    Two new drugs for tardive dyskinesia, involuntary movements of the face and jaw, could be on the market in 2017—valbenazine and deutetrabenazine. Neurocrine Biosciences submitted a New Drug Application for the first in August 2016, while Teva received breakthrough therapy designation status in 2015.

    Other new drugs are targeting more common chronic diseases. The FDA approved Bevespi Aerosphere, a combination of glycopyrrolate and formoterol fumarate, to treat chronic obstructive pulmonary disease, in April 2016. The product with its new co-suspension technology, which helps maintain consistent dosing for a combination of drugs in a single inhaler, competes with two other dual bronchodilators already on the market.

    Mari Edlin, a frequent contributor to Managed Healthcare Executive, is based in Sonoma, California.

    Mari Edlin
    Mari Edlin is a frequent contributor to Managed Healthcare Executive. She is based in Sonoma, California.

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    • perfectukc@------.com
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    • drsunshinesolutioncenter12@------.com
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    • perfectukc@------.com
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    • perfectukc@------.com
      I Am Here Again To Say A Big Thanks To Dr.Sebi For Making Me A Complete woman Again, I Was Infected With Herpes For 5 Years I Have Been Seriously Praying To God And Searching For Cure. I Came Here Last Month To Search For Solution To My Problem And I Saw A Comment Of People Talking About Different Doctors And God Directed Me To Choose Dr.Sebi And I Contacted Him, He Sent Me A Medicine And Directed Me On How I Will Take The Medicine For 7 Days, I Did So And Went For A Test And My Result Came Out As Negative. I Am So Happy, I Shared Tears Of Happiness And I Have Taken It Upon My Self To Always Testify About How God Used Dr.Sebi To Solve My Problem. I Am A Clean woman Now, Without Any Virus If You Are Infected With Any Disease Like HIV AIDS, CANCER ,HERPES Or Any Other Disease You Can Also Be Happy Like Me By Contacting Dr Sebi Through His Email [email protected] or Whatsapp number +2348153863900
    • charlesxavi096@------.com
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    • perfectukc@------.com
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    • charlesxavi096@------.com
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    • perfectukc@------.com
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    • MIZEXNELSON@------.com
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    • MIZEXNELSON@------.com
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    • suzpatrick1@------.com
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    • suzpatrick1@------.com
      Hello my dear viewers,I am Suzan Patrick, i will say to the world to celebrate with me on this numerous testimony, i never believe i could ever get rid of this horrible disease until one fateful day,my story and appreciation goes to Dr.Bude the powerful great doctor that help me to cure my HIV/AIDS disease from my life,he is truly a truthful man with high herbs power's he uses on saving people's life, just a few days back i came in contact with Dr.Bude emails which many individuals have testify so much about of his kind work, so i decided and contacted him quickly because the disease was almost at the last minute of taking my life, i have tried all remedies from several physicians from hospitals but none could help me apart from Dr.Bude who finally cure my HIV/AIDS disease, i was amazed and overwhelmed when the doctor confirmed me negative in the same hospital i have been before,i wish to anyone that is sick today and want healing to please contact this doctor ([email protected]) so if you have any problem HIV, HERPES, CANCER, ALS,HEPATITIS B, DIABETIC,or call +2349035820114.
    • suzpatrick1@------.com
      Hello my dear viewers,I am Suzan Patrick, i will say to the world to celebrate with me on this numerous testimony, i never believe i could ever get rid of this horrible disease until one fateful day,my story and appreciation goes to Dr.Bude the powerful great doctor that help me to cure my HIV/AIDS disease from my life,he is truly a truthful man with high herbs power's he uses on saving people's life, just a few days back i came in contact with Dr.Bude emails which many individuals have testify so much about of his kind work, so i decided and contacted him quickly because the disease was almost at the last minute of taking my life, i have tried all remedies from several physicians from hospitals but none could help me apart from Dr.Bude who finally cure my HIV/AIDS disease, i was amazed and overwhelmed when the doctor confirmed me negative in the same hospital i have been before,i wish to anyone that is sick today and want healing to please contact this doctor ([email protected]) so if you have any problem HIV, HERPES, CANCER, ALS,HEPATITIS B, DIABETIC,or call +2349035820114.
    • clifffordjones889@------.com
      Well done sir. for helping millions of people around the globe to know that you are there to save them. I'm also very grateful to have met you. when i have suffered Diabetes type 2 for more than 8years and also visited several places and finally found you are the very stage of giving up. i will appreciate when i some people testify of how you have cure theirs HIV aids. Herpes disease. Hepatitis B. High blood pressure. arthritis. brain disease. multiple sclerosis and so on. when i went through all this different testimony. and i knew i was at my final place to be cured and when i emailed him on his email:[email protected] and he wrote back after so few minutes. telling me i will suffer no more once i get his medicine and use it. i will see the wonderful work of his herbal herbs. i beckoned on his words and gave him what he needed to prepare my cure and he sent to me and told me how to take it and should go and test my self after the last day. which i did and my result was very overwhelming. if there is so many herbal doctors are out there like Dr Okusu. the world will be in a better hand. contact him today if you need help like i did. on his Mobile:+2349037835860 or his email:[email protected]
    • clifffordjones889@------.com
      Well done sir. for helping millions of people around the globe to know that you are there to save them. I'm also very grateful to have met you. when i have suffered Diabetes type 2 for more than 8years and also visited several places and finally found you are the very stage of giving up. i will appreciate when i some people testify of how you have cure theirs HIV aids. Herpes disease. Hepatitis B. High blood pressure. arthritis. brain disease. multiple sclerosis and so on. when i went through all this different testimony. and i knew i was at my final place to be cured and when i emailed him on his email:[email protected] and he wrote back after so few minutes. telling me i will suffer no more once i get his medicine and use it. i will see the wonderful work of his herbal herbs. i beckoned on his words and gave him what he needed to prepare my cure and he sent to me and told me how to take it and should go and test my self after the last day. which i did and my result was very overwhelming. if there is so many herbal doctors are out there like Dr Okusu. the world will be in a better hand. contact him today if you need help like i did. on his Mobile:+2349037835860 or his email:[email protected] or visit his website:https://drokususolutiontem.wixsite.com/dr-okusu
    • Anonymous
      Hello, I am so happy that is why i take it upon my self to broadcast about Dr Abai, He is a great Herbal doctor enrich herbally by God he cured me of HERPES disease. He has done great research on herbal cure for deadly diseases and he is very able to cure many deadly diseases such as HERPES, HEPATITIS, LASSA FEVER, GONORRHEA, HIV/AIDS, LOW SPERM COUNT, MENOPAUSE DISEASE, EPILEPSY, ASEPSIS, Gonorrhea/Staphylococcus, Weak ejaculation, Weak erection etc. He can also help you get your ex lover back. Dr Abai Natural Herbal Medicine is the best, He cured me and my partner of one of the above deadly disease and we are completely negative now without any side effect i guarantee that you will get your problem solved with Dr Abai Natural Herbal Medicine, visit Dr Abai website: drabaiherbalcure.webs.com and contact him through his WHATS-APP NUMBER +2348156769001, or contact him via email, [email protected]
    • beckettasheley@------.com
      Hello, I am so happy that is why i take it upon my self to broadcast about Dr Abai, He is a great Herbal doctor enrich herbally by God he cured me of HERPES disease. He has done great research on herbal cure for deadly diseases and he is very able to cure many deadly diseases such as HERPES, HEPATITIS, LASSA FEVER, GONORRHEA, HIV/AIDS, LOW SPERM COUNT, MENOPAUSE DISEASE, EPILEPSY, ASEPSIS, Gonorrhea/Staphylococcus, Weak ejaculation, Weak erection etc. He can also help you get your ex lover back. Dr Abai Natural Herbal Medicine is the best, He cured me and my partner of one of the above deadly disease and we are completely negative now without any side effect i guarantee that you will get your problem solved with Dr Abai Natural Herbal Medicine, and contact him through his WHATS-APP NUMBER +2348156769001, or contact him via email, [email protected]
    • Anonymous
      i want to share this great and wonderful testimony to the general public on how i got cured from my sickness called (HEPATITIS B) by DR OGUN healing herbal medicine , I have been suffering from (HEPATITIS B) for good 6 years now and I was almost going to the end of my life due to the constant pain, especially in my LIVER . all I have in my mind is let me just give up because life was no longer intestine to me any more but I just pray to God every day to accept my soul when ever I die, luckily to me , my kid sister ran to me that she found a doctor in the internet who can cure (HEPATITIS B, HERPES,CANCER, and HIV/AIDS ) she helped me out on everything, the great Dr OGUN only ask for my Details and some items , so that he can prepare a Herbal medicine for me and send it to me in my country , which i did.. so after two days of getting the medicine and taking it as prescribe to me from him , I started getting more stronger my blood started flowing normally , i started experiencing changes all over my Body as the great DR OGUN assured me that i should go for medical check up that i have been cured, so after some time i went to my doctor to confirmed if i have be finally healed , behold it was TRUE and i was very Happy ,so if you have HERPES , HEPATITIS B ,CANCER , HIV/AIDS or any kind of sickness YOU HAVE , you can contact him and, any illness get cured, i advice you all to contact himon Via mail at ([email protected]) whatsapp number +2349071799626 Good luck.
    • perfectukc@------.com
      I Am Here Again To Say A Big Thanks To Dr.Sebi Fori Making Me A Complete woman Again, I Was Infected With Herpes For 5 Years I Have Been Seriously Praying To God And Searching For Cure. I Came Here Last Month To Search For Solution To My Problem And I Saw A Comment Of People Talking About Different Doctors And God Directed Me To Choose Dr.Sebi And I Contacted Him, He Sent Me A Medicine And Directed Me On How I Will Take The Medicine For 7 Days, I Did So And Went For A Test And My Result Came Out As Negative. I Am So Happy, I Shared Tears Of Happiness And I Have Taken It Upon My Self To Always Testify About How God Used Dr.Sebi To Solve My Problem. I Am A Clean woman Now, Without Any Virus If You Are Infected With Any Disease Like HIV, AIDS, CANCER HERPES Or Any Other Disease You Can Also Be Happy Like Me By Contacting Dr Sebi Through His Email: [email protected] Or Whatsapp +2348153863900
    • UBM User
      Unbeleivable that they are still missing the mark on where healthcare should focus resources and it is mental health to include drug and alcohol addiction, depression, bipolar disease, ADHD, ADD. They are repeating the same mistakes because for a high of all these disease processes they are choosing to pour money in research into have their beginnings and cores in the mental health. Obesity for many is sugar addiction, food addiction and obsessive compulsive behavioural disorders. All this will do is bandaid the problem and I doubt if even it does that much good. Causes and conditions need to be the center of these conversations in medical fraternity.
    • UBM User
      Unbeleivable that there is such a focus on the conditions and not the causes. We are still missing the mark on where healthcare should focus resources and it is in mental health to include drug and alcohol addiction, depression, bipolar disease, ADHD, ADD. We are repeating the same mistakes vy not addressing behavioural health because for a high percentage of the disease mentioned are caused from underlying mental health problems. It appears we are choosing to pour money in research of the samne things to no avail. Instead we should pour it into mental health. Obesity for many is sugar addiction, food addiction and obsessive compulsive behavioural disorders. All this will do is bandaid the problem and I doubt if even it does that much good. Causes and conditions need to be the center of these conversations in medical fraternity.
    • essayreviews123@------.com
      You have shared some useful updates here. It will help to know about the oncology department and cancer patients are waiting for better medicines to cure their diseases. Essay writing service

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