/ Print /

  • linkedin
  • Increase Font
  • Sharebar

    Innovative strategies help fight multiple myeloma: What every exec should know

    Major advances have occurred over the past two decades in treating multiple myeloma, and these advances are progressing rapidly today, says Gerry Messerschmidt, MD, FACP, chief medical officer of Precision Oncology. Many innovative strategies and combinations of approved and experimental therapies have a high likelihood of gaining approval and becoming standard use. “This means more therapy, more often, and thus, potential financial ramifications for payers of myeloma treatment,” Messerschmidt said.

    As a clinical oncologist and an executive with a leading oncology development provider specializing in clinical trial execution, biomarker services, and analytics, Messerschmidt is tuned into the changes in the myeloma landscape.

    Managed Healthcare Executive (MHE) recently spoke with Messerschmidt about new therapies on the radar, and how they could impact treatment.

    MHE: What are healthcare executives’ major challenges in the area of multiple myeloma?

    MesserschmidtMesserschmidtMesserschmidt: The main challenge for healthcare executives is maintaining a working understanding of approved therapy and standard therapy versus experimental therapy. Today, proteasome inhibitors (PIs), immune modulators (IMiDs), and a steroid are standard and approved therapies, as are many chemotherapies. First-line therapy is usually 2 or 3 drugs and, if possible, many recommend autologous hematopoietic stem cell transplant, once or more than once. Transplants are neither approved by regulatory agencies nor reviewed; however, one transplant is clear standard therapy in many institutions and more than one is often standard in select institutions. Data support both positions.

    Many newer drugs are also in development to treat multiple myeloma and will be arriving on the market this year and over the next several years. Maintaining a working knowledge of these products and their pros and cons compared with other drugs requires examining information from the drug developer, the literature and the providers.

    The healthcare executive must rely on hematologists and pharmacists to review, discuss, and recommend the drugs and procedures for newly diagnosed multiple myeloma through last therapy. All will need to recognize that an algorithm designed today could be outdated in several months. Rapid additions of new therapies and clinical data measuring interventions will continually occur over the next decade.

    MHE: How can these challenges be met or avoided?

    Messerschmidt: Decisions to incorporate therapies into a standard treatment design can be based on the literature, experiencing meeting presentations by experts, FDA approval, and other data reviews available. However, direct experience by the site with these new drugs and procedures can also provide physicians, pharmacists, and healthcare specialists with invaluable experience. Participating in many clinical trials allows hospitals and clinics to understand these new therapies more closely and assess based on prior experience.

    This often occurs in private practice groups by actually using a newly approved drug on several appropriate patients and assessing the efficacy and toxicity with their patients. This is not possible in many treatment situations where only formulary or approved and paid-for cancer products are available.

    Clinical trials often provide cancer patients with new, cutting-edge therapies while offering healthcare experts the firsthand experience that can expedite data review and formulary selection when approved.

    Next: What are some promising developments readers should watch?



    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • [email protected]
      Health is not just physical health, but also mental, emotional and spiritual well-being. An important part of the healing process for me is to be active in HERPES SIMPLEX VIRUS education, support and advocacy. I volunteer in a number of HSV organizations, and in particular Positive Women, because the impact of HSV on women is very different than from men. As once a positive person, I will forever be grateful to God Almighty and Doctor Idahosa to reach me when i thought it is all over, Today am happy with my family living free after the medical doctor have confirmed my HSV status Negative, I have never in my life believed that HSV could be cured by any herbal medicine, I want to make sure that HSV never happens to anyone else. We can't prevent HSV by punishment, by stigma and discrimination. It's only through building a safe, supportive and caring environment, that positive people still have hope and they should contact Dr Idahosa with this email:[email protected] so they can once again be visible in our community, to educate and advocate, to take better care of ourselves and our families. We're someone's daughter, partner, mother, grandmother, sister, aunt. When we have HSV, it impacts on our families too. kindly contact him today and leave carefree, mind you, this spell doctor also have remedy for the following:HIV AIDS, HERPES 1 AND 2, MND, Epilepsy, Leukemia, Asthma, Cancer, Gonorrhea e.t.c.Good luck. the doctor's mail once again is [email protected] or whatsapp him via +2347033330164
    • Anonymous
      Hello Everyone I Wish To Inform The General Public How I Was Cured From (HIV VIRUS That Lasted In My System For 3yrs) By Dr Ezomo I Visited Different Hospitals But They Gave Me List Of Drugs Which Is Very Expensive To Treat The Symptoms And Never Cured Me. I Was Really Loosen My Mind By Thinking And Worried That I Wont Get Cured, one morning i Was Browsing Through The Internet Searching For Remedy When I Saw Comment Of People Talking About How Dr Ezomo Cured Them, Some Speak Of His Cure For Herpes, Cancer, Siphilis And Many More And I Was Curious About It, I Contacted Dr Ezomo Via His Website I Saw Online He Asured Me That I Will Get Cured Then He Told Me What I Need To Do Which I Did Without Hesitation Before three Days He Sent An Herbal Medicine To Me That I Took And The Herbal Medicine Was Really Active According To Him I Took The Medicine, Week later I went for check up to my greatest surprise My Hiv Result Came Out Negative. I’m Cured, You Can Also Get Yourself Cured My Friends Through Dr Ezomo Who GOd Used To Put Smiles On My Face Again, Believe It Or Not Everything Is Possible And Dr Ezomo Is For Real. You Can Reach Him through The Following: EMAIL: [email protected] WhatsApp number: +2347017524691 God bless you Ezomo

    Follow Us On Twitter

    Find us on Facebook

    Latest Tweets Follow